Down-regulation of placental mTOR, insulin/IGF-I signaling, and nutrient transporters in response to maternal nutrient restriction in the baboon

The mechanisms by which maternal nutrient restriction (MNR) causes reduced fetal growth are poorly understood. We hypothesized that MNR inhibits placental mechanistic target of rapamycin (mTOR) and insulin/IGF-I signaling, down-regulates placental nutrient transporters, and decreases fetal amino aci...

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Hlavní autoři: Kavitha, Jovita V., Rosario, Fredrick J., Nijland, Mark J., McDonald, Thomas J., Wu, Guoyao, Kanai, Yoshikatsu, Powell, Theresa L., Nathanielsz, Peter W., Jansson, Thomas
Médium: Artigo
Jazyk:Inglês
Vydáno: Federation of American Societies for Experimental Biology 2014
Témata:
Research Communications
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3929672/
https://ncbi.nlm.nih.gov/pubmed/24334703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.13-242271
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