Down-regulation of placental mTOR, insulin/IGF-I signaling, and nutrient transporters in response to maternal nutrient restriction in the baboon

The mechanisms by which maternal nutrient restriction (MNR) causes reduced fetal growth are poorly understood. We hypothesized that MNR inhibits placental mechanistic target of rapamycin (mTOR) and insulin/IGF-I signaling, down-regulates placental nutrient transporters, and decreases fetal amino aci...

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Huvudupphovsmän: Kavitha, Jovita V., Rosario, Fredrick J., Nijland, Mark J., McDonald, Thomas J., Wu, Guoyao, Kanai, Yoshikatsu, Powell, Theresa L., Nathanielsz, Peter W., Jansson, Thomas
Materialtyp: Artigo
Språk:Inglês
Publicerad: Federation of American Societies for Experimental Biology 2014
Ämnen:
Research Communications
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3929672/
https://ncbi.nlm.nih.gov/pubmed/24334703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.13-242271
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