Down-regulation of placental mTOR, insulin/IGF-I signaling, and nutrient transporters in response to maternal nutrient restriction in the baboon

The mechanisms by which maternal nutrient restriction (MNR) causes reduced fetal growth are poorly understood. We hypothesized that MNR inhibits placental mechanistic target of rapamycin (mTOR) and insulin/IGF-I signaling, down-regulates placental nutrient transporters, and decreases fetal amino aci...

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Detalhes bibliográficos
Main Authors: Kavitha, Jovita V., Rosario, Fredrick J., Nijland, Mark J., McDonald, Thomas J., Wu, Guoyao, Kanai, Yoshikatsu, Powell, Theresa L., Nathanielsz, Peter W., Jansson, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2014
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3929672/
https://ncbi.nlm.nih.gov/pubmed/24334703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.13-242271
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