Identification of the KDM2/7 Histone Lysine Demethylase Subfamily Inhibitor and its Antiproliferative Activity

[Image: see text] Histone N(ε)-methyl lysine demethylases KDM2/7 have been identified as potential targets for cancer therapies. On the basis of the crystal structure of KDM7B, we designed and prepared a series of hydroxamate analogues bearing an alkyl chain. Enzyme assays revealed that compound 9 p...

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Bibliografiske detaljer
Main Authors: Suzuki, Takayoshi, Ozasa, Hiroki, Itoh, Yukihiro, Zhan, Peng, Sawada, Hideyuki, Mino, Koshiki, Walport, Louise, Ohkubo, Rei, Kawamura, Akane, Yonezawa, Masato, Tsukada, Yuichi, Tumber, Anthony, Nakagawa, Hidehiko, Hasegawa, Makoto, Sasaki, Ryuzo, Mizukami, Tamio, Schofield, Christopher J., Miyata, Naoki
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2013
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3929130/
https://ncbi.nlm.nih.gov/pubmed/23964788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm400624b
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