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Identification of the KDM2/7 Histone Lysine Demethylase Subfamily Inhibitor and its Antiproliferative Activity
[Image: see text] Histone N(ε)-methyl lysine demethylases KDM2/7 have been identified as potential targets for cancer therapies. On the basis of the crystal structure of KDM7B, we designed and prepared a series of hydroxamate analogues bearing an alkyl chain. Enzyme assays revealed that compound 9 p...
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| Main Authors: | , , , , , , , , , , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American
Chemical Society
2013
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| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3929130/ https://ncbi.nlm.nih.gov/pubmed/23964788 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm400624b |
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