Identification of ryuvidine as a KDM5A inhibitor

KDM5 family members (A, B, C and D) that demethylate H3K4me3 have been shown to be involved in human cancers. Here we performed screening for KDM5A inhibitors from chemical libraries using the AlphaScreen method and identified a battery of screening hits that inhibited recombinant KDM5A. These compo...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Mitsui, Eishin, Yoshida, Shogo, Shinoda, Yui, Matsumori, Yasumasa, Tsujii, Hiroshi, Tsuchida, Mie, Wada, Shuichi, Hasegawa, Makoto, Ito, Akihiro, Mino, Koshiki, Onuki, Tetsuo, Yoshida, Minoru, Sasaki, Ryuzo, Mizukami, Tamio
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6616564/
https://ncbi.nlm.nih.gov/pubmed/31289306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-46346-x
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