Cooperative transcriptional repression by BCL6 and BACH2 in germinal center B-cell differentiation

The transcriptional repressors BCL6 and BACH2 are crucial regulators of germinal center (GC) B-cell fate, and are known to interact and repress transcription of PRDM1, a key driver of plasma cell differentiation. How these factors cooperate is not fully understood. Herein, we show that GC formation...

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Bibliographic Details
Main Authors: Huang, Chuanxin, Geng, Huimin, Boss, Isaac, Wang, Ling, Melnick, Ari
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2014
Subjects:
Immunobiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3924924/
https://ncbi.nlm.nih.gov/pubmed/24277074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-07-518605
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