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Reversible disruption of BCL6 repression complexes by CD40 signaling in normal and malignant B cells
Germinal center (GC) B cells undergo somatic hypermutation, class switch recombination, and rapid clonal expansion to produce high-affinity antibodies. The BCL6 transcriptional repressor facilitates this phenotype because it can repress DNA damage checkpoint genes. GC B and T cells can make transien...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society of Hematology
2008
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2481532/ https://ncbi.nlm.nih.gov/pubmed/18487509 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-01-131813 |
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