Reversible disruption of BCL6 repression complexes by CD40 signaling in normal and malignant B cells

Germinal center (GC) B cells undergo somatic hypermutation, class switch recombination, and rapid clonal expansion to produce high-affinity antibodies. The BCL6 transcriptional repressor facilitates this phenotype because it can repress DNA damage checkpoint genes. GC B and T cells can make transien...

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Autores principales: Polo, Jose M., Ci, Weimin, Licht, Jonathan D., Melnick, Ari
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2008
Materias:
Immunobiology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2481532/
https://ncbi.nlm.nih.gov/pubmed/18487509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-01-131813
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