Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs

OBJECTIVES: Trypanosoma brucei drug transporters include the TbAT1/P2 aminopurine transporter and the high-affinity pentamidine transporter (HAPT1), but the genetic identity of HAPT1 is unknown. We recently reported that loss of T. brucei aquaglyceroporin 2 (TbAQP2) caused melarsoprol/pentamidine cr...

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Bibliografski detalji
Glavni autori: Munday, Jane C., Eze, Anthonius A., Baker, Nicola, Glover, Lucy, Clucas, Caroline, Aguinaga Andrés, David, Natto, Manal J., Teka, Ibrahim A., McDonald, Jennifer, Lee, Rebecca S., Graf, Fabrice E., Ludin, Philipp, Burchmore, Richard J. S., Turner, C. Michael R., Tait, Andy, MacLeod, Annette, Mäser, Pascal, Barrett, Michael P., Horn, David, De Koning, Harry P.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2014
Teme:
Original Research
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3922157/
https://ncbi.nlm.nih.gov/pubmed/24235095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkt442
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