Instability of aquaglyceroporin (AQP) 2 contributes to drug resistance in Trypanosoma brucei

Defining mode of action is vital for both developing new drugs and predicting potential resistance mechanisms. Sensitivity of African trypanosomes to pentamidine and melarsoprol is predominantly mediated by aquaglyceroporin 2 (TbAQP2), a channel associated with water/glycerol transport. TbAQP2 is ex...

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Detaylı Bibliyografya
Yayımlandı:PLoS Negl Trop Dis
Asıl Yazarlar: Quintana, Juan F., Bueren-Calabuig, Juan, Zuccotto, Fabio, de Koning, Harry P., Horn, David, Field, Mark C.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2020
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7413563/
https://ncbi.nlm.nih.gov/pubmed/32644992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0008458
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