The epigenetic modifier trichostatin A, a histone deacetylase inhibitor, suppresses proliferation and epithelial–mesenchymal transition of lens epithelial cells

Proliferation and epithelial–mesenchymal transition (EMT) of lens epithelium cells (LECs) may contribute to anterior subcapsular cataract (ASC) and posterior capsule opacification (PCO), which are important causes of visual impairment. Histone deacetylases (HDACs)-mediated epigenetic mechanism has a...

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Main Authors: Chen, X, Xiao, W, Chen, W, Luo, L, Ye, S, Liu, Y
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2013
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3920942/
https://ncbi.nlm.nih.gov/pubmed/24157878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.416
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