Trichostatin A, a histone deacetylase inhibitor, suppresses proliferation and epithelial–mesenchymal transition in retinal pigment epithelium cells

The proliferation and epithelial–mesenchymal transition (EMT) of retinal pigment epithelium (RPE) cells are the major pathological changes in development of proliferative vitreoretinopathy (PVR), which leads to severe visual impairment. Histone deacetylases (HDACs)-mediated epigenetic mechanisms pla...

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Detalhes bibliográficos
Main Authors: Xiao, Wei, Chen, Xiaoyun, Liu, Xialin, Luo, Lixia, Ye, Shaobi, Liu, Yizhi
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons Ltd 2014
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4000116/
https://ncbi.nlm.nih.gov/pubmed/24456602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.12212
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