The epigenetic modifier trichostatin A, a histone deacetylase inhibitor, suppresses proliferation and epithelial–mesenchymal transition of lens epithelial cells

Proliferation and epithelial–mesenchymal transition (EMT) of lens epithelium cells (LECs) may contribute to anterior subcapsular cataract (ASC) and posterior capsule opacification (PCO), which are important causes of visual impairment. Histone deacetylases (HDACs)-mediated epigenetic mechanism has a...

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Detalhes bibliográficos
Main Authors: Chen, X, Xiao, W, Chen, W, Luo, L, Ye, S, Liu, Y
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3920942/
https://ncbi.nlm.nih.gov/pubmed/24157878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.416
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