A Histone Deacetylase Inhibitor Suppresses Epithelial-Mesenchymal Transition and Attenuates Chemoresistance in Biliary Tract Cancer

Epithelial-mesenchymal transition (EMT) is involved in the characteristics of malignancy, such as invasion, metastasis, and chemoresistance. In biliary tract cancer (BTC), EMT is induced by transforming growth factor-beta 1 (TGF-β1). The EMT is reversible; therefore, it is conceivable that it could...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Sakamoto, Takuya, Kobayashi, Shogo, Yamada, Daisaku, Nagano, Hiroaki, Tomokuni, Akira, Tomimaru, Yoshito, Noda, Takehiro, Gotoh, Kunihito, Asaoka, Tadafumi, Wada, Hiroshi, Kawamoto, Koichi, Marubashi, Shigeru, Eguchi, Hidetoshi, Doki, Yuichiro, Mori, Masaki
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4699768/
https://ncbi.nlm.nih.gov/pubmed/26726879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0145985
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