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Single-molecule characterization of Fen1 and Fen1/PCNA complexes acting on flap substrates
Flap endonuclease 1 (Fen1) is a highly conserved structure-specific nuclease that catalyses a specific incision to remove 5′ flaps in double-stranded DNA substrates. Fen1 plays an essential role in key cellular processes, such as DNA replication and repair, and mutations that compromise Fen1 express...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3919604/ https://ncbi.nlm.nih.gov/pubmed/24234453 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt1116 |
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