Domain swapping between FEN-1 and XPG defines regions in XPG that mediate nucleotide excision repair activity and substrate specificity

FEN-1 and XPG are members of the FEN-1 family of structure-specific nucleases, which share a conserved active site. FEN-1 plays a central role in DNA replication, whereas XPG is involved in nucleotide excision repair (NER). Both FEN-1 and XPG are active on flap structures, but only XPG cleaves bubbl...

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Bibliographic Details
Main Authors: Hohl, Marcel, Dunand-Sauthier, Isabelle, Staresincic, Lidija, Jaquier-Gubler, Pascale, Thorel, Fabrizio, Modesti, Mauro, Clarkson, Stuart G., Schärer, Orlando D.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2007
Subjects:
Nucleic Acid Enzymes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1888826/
https://ncbi.nlm.nih.gov/pubmed/17452369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm092
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