Domain swapping between FEN-1 and XPG defines regions in XPG that mediate nucleotide excision repair activity and substrate specificity

FEN-1 and XPG are members of the FEN-1 family of structure-specific nucleases, which share a conserved active site. FEN-1 plays a central role in DNA replication, whereas XPG is involved in nucleotide excision repair (NER). Both FEN-1 and XPG are active on flap structures, but only XPG cleaves bubbl...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Hohl, Marcel, Dunand-Sauthier, Isabelle, Staresincic, Lidija, Jaquier-Gubler, Pascale, Thorel, Fabrizio, Modesti, Mauro, Clarkson, Stuart G., Schärer, Orlando D.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2007
Assuntos:
Nucleic Acid Enzymes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1888826/
https://ncbi.nlm.nih.gov/pubmed/17452369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm092
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados