PCNA stimulates catalysis by structure-specific nucleases using two distinct mechanisms: substrate targeting and catalytic step

The sliding clamp Proliferating Cell Nuclear Antigen (PCNA) functions as a recruiter and organizer of a wide variety of DNA modifying enzymes including nucleases, helicases, polymerases and glycosylases. The 5′-flap endonuclease Fen-1 is essential for Okazaki fragment processing in eukaryotes and ar...

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Bibliografiset tiedot
Päätekijät: Hutton, Richard D., Roberts, Jennifer A., Penedo, J. Carlos, White, Malcolm F.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2008
Aiheet:
Nucleic Acid Enzymes
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2588518/
https://ncbi.nlm.nih.gov/pubmed/18948279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn745
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