The Mechanism of Kindlin-mediated Activation of Integrin αIIbβ3

Increased ligand binding to cellular integrins (“activation”) plays important roles in processes such as development, cell migration, extracellular matrix assembly, tumor metastasis and hemostasis and thrombosis[1-5]. Integrin activation encompasses both increased integrin monomer affinity and incre...

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Main Authors: Ye, Feng, Petrich, Brian G., Anekal, Praju, Lefort, Craig T., Kasirer-Friede, Ana, Shattil, Sanford J., Moser, Markus, Fässler, Reinhard, Ginsberg, Mark H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3912999/
https://ncbi.nlm.nih.gov/pubmed/24210614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2013.09.050
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