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Switching a Replication-Defective Adenoviral Vector into a Replication-Competent, Oncolytic Adenovirus
The adenovirus immediate early gene E1A initiates the program of viral gene transcription and reprograms multiple aspects of cell function and behavior. For adenoviral (Ad) vector-mediated gene transfer and therapy approaches, where replication-defective (RD) gene transfer is required, E1A has thus...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Society for Microbiology
2014
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3911754/ https://ncbi.nlm.nih.gov/pubmed/24155386 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02668-13 |
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