A fully replication-competent adenovirus vector with enhanced oncolytic properties

We have studied the oncolytic efficacy of two adenovirus vectors named KD3 and INGN 007, which differ from each other only in that whereas KD3 has two small deletions in its e1a gene that restrict its replication to rapidly cycling cells, INGN 007 has wild-type e1a gene. Both vectors overexpress the...

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Bibliographic Details
Main Authors: Toth, K, Kuppuswamy, M, Shashkova, EV, Spencer, JF, Wold, WSM
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3437749/
https://ncbi.nlm.nih.gov/pubmed/20596091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cgt.2010.33
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