Tumor-Specific, Replication-Competent Adenovirus Vectors Overexpressing the Adenovirus Death Protein

We have constructed two novel adenovirus (Ad) replication-competent vectors, named KD1 and KD3, that may have use in anticancer therapy. The vectors have two key features. First, they markedly overexpress the Ad death protein (ADP), an Ad nuclear membrane glycoprotein required at late stages of infe...

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Autores principales: Doronin, Konstantin, Toth, Karoly, Kuppuswamy, Mohan, Ward, Peter, Tollefson, Ann E., Wold, William S. M.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2000
Materias:
Gene Therapy
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC112113/
https://ncbi.nlm.nih.gov/pubmed/10846098
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