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Anticancer activity of oncolytic adenovirus vector armed with IFN-α and ADP is enhanced by pharmacologically controlled expression of TRAIL

We have previously described oncolytic adenovirus (Ad) vectors KD3 and KD3–interferon (IFN) that were rendered cancer-specific by mutations in the E1A region of Ad; these mutations abolish binding of E1A proteins to p300/CBP and pRB. The antitumor activity of the vectors was enhanced by overexpressi...

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Detalhes bibliográficos
Main Authors: Shashkova, EV, Kuppuswamy, MN, Wold, WSM, Doronin, K
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3433948/
https://ncbi.nlm.nih.gov/pubmed/17992200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.cgt.7701107
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