An acute toxicology study with INGN 007, an oncolytic adenovirus vector, in mice and permissive Syrian hamsters; comparisons with wild-type Ad5 and a replication-defective adenovirus vector

Oncolytic (replication-competent) adenoviruses as anticancer agents provide new, promising tools to fight cancer. In support of a Phase I clinical trial, here we report safety data with INGN 007 (VRX-007), an oncolytic adenovirus with increased anti-tumor efficacy due to overexpression of the adenov...

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Hauptverfasser: Lichtenstein, DL, Spencer, JF, Doronin, K, Patra, D, Meyer, JM, Shashkova, EV, Kuppuswamy, M, Dhar, D, Thomas, MA, Tollefson, AE, Zumstein, LA, Wold, WSM, Toth, K
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3433943/
https://ncbi.nlm.nih.gov/pubmed/19197324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cgt.2009.5
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