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Effect of Preexisting Immunity on Oncolytic Adenovirus Vector INGN 007 Antitumor Efficacy in Immunocompetent and Immunosuppressed Syrian Hamsters

Immune responses against adenovirus (Ad) vectors pose a possible concern for the outcome of treatment efficacy. To address the role of preexisting immunity in oncolytic Ad vector antitumor efficacy following intratumoral injection of vector as well as tumor-to-tissue spread of the vector, we employe...

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Bibliografski detalji
Glavni autori: Dhar, Debanjan, Spencer, Jacqueline F., Toth, Karoly, Wold, William S. M.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2009
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2643738/
https://ncbi.nlm.nih.gov/pubmed/19073718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02127-08
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