Pre-existing Immunity and Passive Immunity to Adenovirus 5 Prevents Toxicity Caused by an Oncolytic Adenovirus Vector in the Syrian Hamster Model

We have used Syrian hamsters to examine the role of pre-existing immunity to adenovirus (Ad) 5 in the toxicity of the oncolytic Ad vector INGN 007. Groups of hamsters were or were not immunized with Ad5. Half the hamsters were immunosuppressed using cyclophosphamide (CP), then injected intravenously...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Dhar, Debanjan, Spencer, Jacqueline F, Toth, Karoly, Wold, William SM
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2009
Pynciau:
Original Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835003/
https://ncbi.nlm.nih.gov/pubmed/19602998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.156
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