Pre-existing Immunity and Passive Immunity to Adenovirus 5 Prevents Toxicity Caused by an Oncolytic Adenovirus Vector in the Syrian Hamster Model

We have used Syrian hamsters to examine the role of pre-existing immunity to adenovirus (Ad) 5 in the toxicity of the oncolytic Ad vector INGN 007. Groups of hamsters were or were not immunized with Ad5. Half the hamsters were immunosuppressed using cyclophosphamide (CP), then injected intravenously...

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Detalhes bibliográficos
Main Authors: Dhar, Debanjan, Spencer, Jacqueline F, Toth, Karoly, Wold, William SM
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2009
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835003/
https://ncbi.nlm.nih.gov/pubmed/19602998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.156
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