Expanded Anticancer Therapeutic Window of Hexon-modified Oncolytic Adenovirus

One of the significant hurdles toward safe and efficacious systemic treatment of cancer with oncolytic adenoviruses (Ads) is dose-limiting hepatotoxicity that prevents the increase of a therapeutic dose. In this study, we expanded the therapeutic window of oncolytic serotype 5 Ad (Ad5) by a genetic...

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Bibliografiset tiedot
Päätekijät: Shashkova, Elena V, May, Shannon M, Doronin, Konstantin, Barry, Michael A
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group 2009
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Original Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2814381/
https://ncbi.nlm.nih.gov/pubmed/19755961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.217
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