Novel Immunocompetent Murine Tumor Model for Evaluation of Conditionally Replication-Competent (Oncolytic) Murine Adenoviral Vectors

Oncolytic adenoviral vectors that express immunostimulatory transgenes are currently being evaluated in clinic. Preclinical testing of these vectors has thus far been limited to immunodeficient xenograft tumor models since human adenoviruses do not replicate effectively in murine tumor cells. The ef...

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Autors principals: Robinson, Michael, Li, Betty, Ge, Ying, Ko, Derek, Yendluri, Satya, Harding, Thomas, VanRoey, Melinda, Spindler, Katherine R., Jooss, Karin
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2009
Matèries:
Gene Delivery
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2663273/
https://ncbi.nlm.nih.gov/pubmed/19193803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02561-08
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