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Switching a Replication-Defective Adenoviral Vector into a Replication-Competent, Oncolytic Adenovirus

The adenovirus immediate early gene E1A initiates the program of viral gene transcription and reprograms multiple aspects of cell function and behavior. For adenoviral (Ad) vector-mediated gene transfer and therapy approaches, where replication-defective (RD) gene transfer is required, E1A has thus...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Nakashima, Hiroshi, Chiocca, E. Antonio
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2014
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3911754/
https://ncbi.nlm.nih.gov/pubmed/24155386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02668-13
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