Polo-like Kinase 2, a Novel ADAM17 Signaling Component, Regulates Tumor Necrosis Factor α Ectodomain Shedding

ADAM17 (a disintegrin and metalloprotease 17) controls pro- and anti-inflammatory signaling events by promoting ectodomain shedding of cytokine precursors and cytokine receptors. Despite the well documented substrate repertoire of ADAM17, little is known about regulatory mechanisms, leading to subst...

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Detalhes bibliográficos
Main Authors: Schwarz, Jeanette, Schmidt, Stefanie, Will, Olga, Koudelka, Tomas, Köhler, Kaja, Boss, Melanie, Rabe, Björn, Tholey, Andreas, Scheller, Jürgen, Schmidt-Arras, Dirk, Schwake, Michael, Rose-John, Stefan, Chalaris, Athena
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3908438/
https://ncbi.nlm.nih.gov/pubmed/24338472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.536847
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