Polo-like Kinase 2, a Novel ADAM17 Signaling Component, Regulates Tumor Necrosis Factor α Ectodomain Shedding

ADAM17 (a disintegrin and metalloprotease 17) controls pro- and anti-inflammatory signaling events by promoting ectodomain shedding of cytokine precursors and cytokine receptors. Despite the well documented substrate repertoire of ADAM17, little is known about regulatory mechanisms, leading to subst...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Schwarz, Jeanette, Schmidt, Stefanie, Will, Olga, Koudelka, Tomas, Köhler, Kaja, Boss, Melanie, Rabe, Björn, Tholey, Andreas, Scheller, Jürgen, Schmidt-Arras, Dirk, Schwake, Michael, Rose-John, Stefan, Chalaris, Athena
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2014
Pynciau:
Cell Biology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3908438/
https://ncbi.nlm.nih.gov/pubmed/24338472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.536847
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