Role of ADAMs in the Ectodomain Shedding and Conformational Conversion of the Prion Protein

The cellular prion protein (PrP(C)) is essential for the pathogenesis and transmission of prion diseases. PrP(C) is bound to the plasma membrane via a glycosylphosphatidylinositol anchor, although a secreted, soluble form has also been identified. Previously we reported that PrP(C) is subject to ect...

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Autores principales: Taylor, David R., Parkin, Edward T., Cocklin, Sarah L., Ault, James R., Ashcroft, Alison E., Turner, Anthony J., Hooper, Nigel M.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2009
Materias:
Protein Synthesis, Post-Translational Modification, and Degradation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2755666/
https://ncbi.nlm.nih.gov/pubmed/19564338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.032599
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