Role of ADAMs in the Ectodomain Shedding and Conformational Conversion of the Prion Protein

The cellular prion protein (PrP(C)) is essential for the pathogenesis and transmission of prion diseases. PrP(C) is bound to the plasma membrane via a glycosylphosphatidylinositol anchor, although a secreted, soluble form has also been identified. Previously we reported that PrP(C) is subject to ect...

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Detalhes bibliográficos
Main Authors: Taylor, David R., Parkin, Edward T., Cocklin, Sarah L., Ault, James R., Ashcroft, Alison E., Turner, Anthony J., Hooper, Nigel M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Protein Synthesis, Post-Translational Modification, and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2755666/
https://ncbi.nlm.nih.gov/pubmed/19564338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.032599
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