A Disintegrin and Metalloproteinase 17 (ADAM17) Mediates Inflammation-induced Shedding of Syndecan-1 and -4 by Lung Epithelial Cells

Syndecans are cell surface proteoglycans that bind and modulate various proinflammatory mediators and can be proteolytically shed from the cell surface. Within the lung, syndecan-1 and -4 are expressed as transmembrane proteins on epithelial cells and released in the bronchoalveolar fluid during inf...

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Main Authors: Pruessmeyer, Jessica, Martin, Christian, Hess, Franz M., Schwarz, Nicole, Schmidt, Sven, Kogel, Tanja, Hoettecke, Nicole, Schmidt, Boris, Sechi, Antonio, Uhlig, Stefan, Ludwig, Andreas
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Protein Synthesis, Post-Translational Modification, and Degradation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2804204/
https://ncbi.nlm.nih.gov/pubmed/19875451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.059394
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