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Shedding of Collagen XVII/BP180 in Skin Depends on Both ADAM10 and ADAM9

Collagen XVII is a transmembrane collagen and the major autoantigen of the autoimmune skin blistering disease bullous pemphigoid. Collagen XVII is proteolytically released from the membrane, and the pathogenic epitope harbors the cleavage site for its ectodomain shedding, suggesting that proteolysis...

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Autores principales: Franzke, Claus-Werner, Bruckner-Tuderman, Leena, Blobel, Carl P.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2009
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2749112/
https://ncbi.nlm.nih.gov/pubmed/19574220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.034090
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