Tumor Necrosis Factor-α Convertase (ADAM17) Mediates Regulated Ectodomain Shedding of the Severe-acute Respiratory Syndrome-Coronavirus (SARS-CoV) Receptor, Angiotensin-converting Enzyme-2 (ACE2)

Angiotensin-converting enzyme-2 (ACE2) is a critical regulator of heart function and a cellular receptor for the causative agent of severe-acute respiratory syndrome (SARS), SARS-CoV (coronavirus). ACE2 is a type I transmembrane protein, with an extracellular N-terminal domain containing the active...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Lambert, Daniel W., Yarski, Mike, Warner, Fiona J., Thornhill, Paul, Parkin, Edward T., Smith, A. Ian, Hooper, Nigel M., Turner, Anthony J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. 2005
Schlagworte:
Protein Synthesis, Post-Translation Modification, and Degradation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8062222/
https://ncbi.nlm.nih.gov/pubmed/15983030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M505111200
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