Structural Basis for Inflammation-driven Shedding of CD163 Ectodomain and Tumor Necrosis Factor-α in Macrophages

The haptoglobin-hemoglobin receptor CD163 and proTNF-α are transmembrane macrophage proteins subjected to cleavage by the inflammation-responsive protease ADAM17. This leads to release of soluble CD163 (sCD163) and bioactive TNF-α. Sequence comparison of the juxtamembrane region identified similar p...

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Hlavní autoři: Etzerodt, Anders, Rasmussen, Mie Rostved, Svendsen, Pia, Chalaris, Athena, Schwarz, Jeanette, Galea, Ian, Møller, Holger Jon, Moestrup, Søren Kragh
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2014
Témata:
Membrane Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3887204/
https://ncbi.nlm.nih.gov/pubmed/24275664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.520213
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