Two-Stage Phase I Dose-Escalation Study of Intratumoral Reovirus Type 3 Dearing and Palliative Radiotherapy in Patients with Advanced Cancers

PURPOSE: To determine the safety and feasibility of combining intratumoral reovirus and radiotherapy in patients with advanced cancer and to assess viral biodistribution, reoviral replication in tumors, and antiviral immune responses. EXPERIMENTAL DESIGN: Patients with measurable disease amenable to...

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Autors principals: Harrington, Kevin J., Karapanagiotou, Eleni M., Roulstone, Victoria, Twigger, Katie R., White, Christine L., Vidal, Laura, Beirne, Debbie, Prestwich, Robin, Newbold, Kate, Ahmed, Merina, Thway, Khin, Nutting, Christopher M., Coffey, Matt, Harris, Dean, Vile, Richard G., Pandha, Hardev S., DeBono, Johann S., Melcher, Alan A.
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3907942/
https://ncbi.nlm.nih.gov/pubmed/20484020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-0054
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