Two-Stage Phase I Dose-Escalation Study of Intratumoral Reovirus Type 3 Dearing and Palliative Radiotherapy in Patients with Advanced Cancers

PURPOSE: To determine the safety and feasibility of combining intratumoral reovirus and radiotherapy in patients with advanced cancer and to assess viral biodistribution, reoviral replication in tumors, and antiviral immune responses. EXPERIMENTAL DESIGN: Patients with measurable disease amenable to...

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Detalhes bibliográficos
Main Authors: Harrington, Kevin J., Karapanagiotou, Eleni M., Roulstone, Victoria, Twigger, Katie R., White, Christine L., Vidal, Laura, Beirne, Debbie, Prestwich, Robin, Newbold, Kate, Ahmed, Merina, Thway, Khin, Nutting, Christopher M., Coffey, Matt, Harris, Dean, Vile, Richard G., Pandha, Hardev S., DeBono, Johann S., Melcher, Alan A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3907942/
https://ncbi.nlm.nih.gov/pubmed/20484020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-0054
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