The Effect of Cell Cycle Synchronization on Tumor Sensitivity to Reovirus Oncolysis

The potential for increased sensitivity of tumor cells to oncolytic reovirus by altering the normal cell cycle using clinically available pharmacological agents was investigated. B16.F10 mouse melanoma cells were partially synchronized with hydroxyurea, thymidine, or by mitotic shake-off. Cell survi...

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Detalhes bibliográficos
Main Authors: Heinemann, Lucy, Simpson, Guy R, Annels, Nicola E, Vile, Richard, Melcher, Alan, Prestwich, Robin, Harrington, Kevin J, Pandha, Hardev S
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2997589/
https://ncbi.nlm.nih.gov/pubmed/20842107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.189
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