Phase I/II Trial of Carboplatin and Paclitaxel Chemotherapy in Combination with Intravenous Oncolytic Reovirus in Patients with Advanced Malignancies

PURPOSE: Reovirus type 3 Dearing (RT3D) replicates preferentially in Ras-activated cancers. RT3D shows synergistic in vitro cytotoxicity in combination with platins and taxanes. The purpose of this phase I/II study was to assess RT3D combined with carboplatin/paclitaxel in patients with advanced can...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Karapanagiotou, Eleni M., Roulstone, Victoria, Twigger, Katie, Ball, Mercel, Tanay, MaryAnne, Nutting, Chris, Newbold, Kate, Gore, Martin E., Larkin, James, Syrigos, Konstantinos N., Coffey, Matt, Thompson, Brad, Mettinger, Karl, Vile, Richard G., Pandha, Hardev S., Hall, Geoff D., Melcher, Alan A., Chester, John, Harrington, Kevin J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5553618/
https://ncbi.nlm.nih.gov/pubmed/22316603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-2181
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