Reovirus exerts potent oncolytic effects in head and neck cancer cell lines that are independent of signalling in the EGFR pathway

BACKGROUND: Reovirus exploits aberrant signalling downstream of Ras to mediate tumor-specific oncolysis. Since ~90% squamous cell carcinomas of the head and neck (SCCHN) over-express EGFR and SCCHN cell lines are sensitive to oncolytic reovirus, we conducted a detailed analysis of the effects of reo...

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Główni autorzy: Twigger, Katie, Roulstone, Victoria, Kyula, Joan, Karapanagiotou, Eleni M, Syrigos, Konstantinos N, Morgan, Richard, White, Christine, Bhide, Shreerang, Nuovo, Gerard, Coffey, Matt, Thompson, Brad, Jebar, Adel, Errington, Fiona, Melcher, Alan A, Vile, Richard G, Pandha, Hardev S, Harrington, Kevin J
Format: Artigo
Język:Inglês
Wydane: BioMed Central 2012
Hasła przedmiotowe:
Research Article
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3537694/
https://ncbi.nlm.nih.gov/pubmed/22920673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-12-368
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