Reovirus exerts potent oncolytic effects in head and neck cancer cell lines that are independent of signalling in the EGFR pathway

BACKGROUND: Reovirus exploits aberrant signalling downstream of Ras to mediate tumor-specific oncolysis. Since ~90% squamous cell carcinomas of the head and neck (SCCHN) over-express EGFR and SCCHN cell lines are sensitive to oncolytic reovirus, we conducted a detailed analysis of the effects of reo...

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Main Authors: Twigger, Katie, Roulstone, Victoria, Kyula, Joan, Karapanagiotou, Eleni M, Syrigos, Konstantinos N, Morgan, Richard, White, Christine, Bhide, Shreerang, Nuovo, Gerard, Coffey, Matt, Thompson, Brad, Jebar, Adel, Errington, Fiona, Melcher, Alan A, Vile, Richard G, Pandha, Hardev S, Harrington, Kevin J
格式: Artigo
語言:Inglês
出版: BioMed Central 2012
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3537694/
https://ncbi.nlm.nih.gov/pubmed/22920673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-12-368
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