Reovirus exerts potent oncolytic effects in head and neck cancer cell lines that are independent of signalling in the EGFR pathway

BACKGROUND: Reovirus exploits aberrant signalling downstream of Ras to mediate tumor-specific oncolysis. Since ~90% squamous cell carcinomas of the head and neck (SCCHN) over-express EGFR and SCCHN cell lines are sensitive to oncolytic reovirus, we conducted a detailed analysis of the effects of reo...

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Autors principals: Twigger, Katie, Roulstone, Victoria, Kyula, Joan, Karapanagiotou, Eleni M, Syrigos, Konstantinos N, Morgan, Richard, White, Christine, Bhide, Shreerang, Nuovo, Gerard, Coffey, Matt, Thompson, Brad, Jebar, Adel, Errington, Fiona, Melcher, Alan A, Vile, Richard G, Pandha, Hardev S, Harrington, Kevin J
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3537694/
https://ncbi.nlm.nih.gov/pubmed/22920673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-12-368
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