High-level transgene expression in induced pluripotent stem cell–derived megakaryocytes: correction of Glanzmann thrombasthenia

Megakaryocyte-specific transgene expression in patient-derived induced pluripotent stem cells (iPSCs) offers a new approach to study and potentially treat disorders affecting megakaryocytes and platelets. By using a Gp1ba promoter, we developed a strategy for achieving a high level of protein expres...

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書誌詳細
主要な著者: Sullivan, Spencer K., Mills, Jason A., Koukouritaki, Sevasti B., Vo, Karen K., Lyde, Randolph B., Paluru, Prasuna, Zhao, Guoha, Zhai, Li, Sullivan, Lisa M., Wang, Yuhuan, Kishore, Siddharth, Gharaibeh, Eyad Z., Lambert, Michele P., Wilcox, David A., French, Deborah L., Poncz, Mortimer, Gadue, Paul
フォーマット: Artigo
言語:Inglês
出版事項: American Society of Hematology 2014
主題:
Platelets and Thrombopoiesis
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3907760/
https://ncbi.nlm.nih.gov/pubmed/24335497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-10-530725
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