High-level transgene expression in induced pluripotent stem cell–derived megakaryocytes: correction of Glanzmann thrombasthenia

Megakaryocyte-specific transgene expression in patient-derived induced pluripotent stem cells (iPSCs) offers a new approach to study and potentially treat disorders affecting megakaryocytes and platelets. By using a Gp1ba promoter, we developed a strategy for achieving a high level of protein expres...

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Hlavní autoři: Sullivan, Spencer K., Mills, Jason A., Koukouritaki, Sevasti B., Vo, Karen K., Lyde, Randolph B., Paluru, Prasuna, Zhao, Guoha, Zhai, Li, Sullivan, Lisa M., Wang, Yuhuan, Kishore, Siddharth, Gharaibeh, Eyad Z., Lambert, Michele P., Wilcox, David A., French, Deborah L., Poncz, Mortimer, Gadue, Paul
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2014
Témata:
Platelets and Thrombopoiesis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3907760/
https://ncbi.nlm.nih.gov/pubmed/24335497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-10-530725
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