High-level transgene expression in induced pluripotent stem cell–derived megakaryocytes: correction of Glanzmann thrombasthenia

Megakaryocyte-specific transgene expression in patient-derived induced pluripotent stem cells (iPSCs) offers a new approach to study and potentially treat disorders affecting megakaryocytes and platelets. By using a Gp1ba promoter, we developed a strategy for achieving a high level of protein expres...

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Detalhes bibliográficos
Main Authors: Sullivan, Spencer K., Mills, Jason A., Koukouritaki, Sevasti B., Vo, Karen K., Lyde, Randolph B., Paluru, Prasuna, Zhao, Guoha, Zhai, Li, Sullivan, Lisa M., Wang, Yuhuan, Kishore, Siddharth, Gharaibeh, Eyad Z., Lambert, Michele P., Wilcox, David A., French, Deborah L., Poncz, Mortimer, Gadue, Paul
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2014
Assuntos:
Platelets and Thrombopoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3907760/
https://ncbi.nlm.nih.gov/pubmed/24335497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-10-530725
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