APOBEC3B is an enzymatic source of mutation in breast cancer

Multiple mutations are required for cancer development, and genome sequencing has revealed that several cancers, including breast, have somatic mutation spectra dominated by C-to-T transitions(1–9). Most of these mutations occur at hydrolytically disfavored(10) non-methylated cytosines throughout th...

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Detalhes bibliográficos
Main Authors: Burns, Michael B., Lackey, Lela, Carpenter, Michael A., Rathore, Anurag, Land, Allison M., Leonard, Brandon, Refsland, Eric W., Kotandeniya, Delshanee, Tretyakova, Natalia, Nikas, Jason B., Yee, Douglas, Temiz, Nuri A., Donohue, Duncan E., McDougle, Rebecca M., Brown, William L., Law, Emily K., Harris, Reuben S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3907282/
https://ncbi.nlm.nih.gov/pubmed/23389445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature11881
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