APOBEC3B is an enzymatic source of mutation in breast cancer

Multiple mutations are required for cancer development, and genome sequencing has revealed that several cancers, including breast, have somatic mutation spectra dominated by C-to-T transitions(1–9). Most of these mutations occur at hydrolytically disfavored(10) non-methylated cytosines throughout th...

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Autori principali: Burns, Michael B., Lackey, Lela, Carpenter, Michael A., Rathore, Anurag, Land, Allison M., Leonard, Brandon, Refsland, Eric W., Kotandeniya, Delshanee, Tretyakova, Natalia, Nikas, Jason B., Yee, Douglas, Temiz, Nuri A., Donohue, Duncan E., McDougle, Rebecca M., Brown, William L., Law, Emily K., Harris, Reuben S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3907282/
https://ncbi.nlm.nih.gov/pubmed/23389445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature11881
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