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Evidence for APOBEC3B mutagenesis in multiple human cancers

Thousands of somatic mutations accrue in most human cancers and causes are largely unknown. We recently showed that the DNA cytosine deaminase APOBEC3B accounts for up to half of the mutational load in breast carcinomas expressing this enzyme. Here, we address whether APOBEC3B is broadly responsible...

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書誌詳細
主要な著者: Burns, Michael B., Temiz, Nuri A., Harris, Reuben S.
フォーマット: Artigo
言語:Inglês
出版事項: 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3902892/
https://ncbi.nlm.nih.gov/pubmed/23852168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.2701
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