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Evidence for APOBEC3B mutagenesis in multiple human cancers
Thousands of somatic mutations accrue in most human cancers and causes are largely unknown. We recently showed that the DNA cytosine deaminase APOBEC3B accounts for up to half of the mutational load in breast carcinomas expressing this enzyme. Here, we address whether APOBEC3B is broadly responsible...
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| 主要な著者: | , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3902892/ https://ncbi.nlm.nih.gov/pubmed/23852168 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.2701 |
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