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Evidence for APOBEC3B mutagenesis in multiple human cancers

Thousands of somatic mutations accrue in most human cancers and causes are largely unknown. We recently showed that the DNA cytosine deaminase APOBEC3B accounts for up to half of the mutational load in breast carcinomas expressing this enzyme. Here, we address whether APOBEC3B is broadly responsible...

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Detalhes bibliográficos
Main Authors: Burns, Michael B., Temiz, Nuri A., Harris, Reuben S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3902892/
https://ncbi.nlm.nih.gov/pubmed/23852168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.2701
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