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Evidence for APOBEC3B mutagenesis in multiple human cancers

Thousands of somatic mutations accrue in most human cancers and causes are largely unknown. We recently showed that the DNA cytosine deaminase APOBEC3B accounts for up to half of the mutational load in breast carcinomas expressing this enzyme. Here, we address whether APOBEC3B is broadly responsible...

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Main Authors: Burns, Michael B., Temiz, Nuri A., Harris, Reuben S.
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3902892/
https://ncbi.nlm.nih.gov/pubmed/23852168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.2701
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