Targeting Low-Druggability Bromodomains: Fragment Based Screening and Inhibitor Design against the BAZ2B Bromodomain

[Image: see text] Bromodomains are epigenetic reader domains that have recently become popular targets. In contrast to BET bromodomains, which have proven druggable, bromodomains from other regions of the phylogenetic tree have shallower pockets. We describe successful targeting of the challenging B...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Ferguson, Fleur M., Fedorov, Oleg, Chaikuad, Apirat, Philpott, Martin, Muniz, Joao R. C., Felletar, Ildiko, von Delft, Frank, Heightman, Tom, Knapp, Stefan, Abell, Chris, Ciulli, Alessio
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Chemical Society 2013
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3905694/
https://ncbi.nlm.nih.gov/pubmed/24304323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm401582c
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