Binding Hotspots of BAZ2B Bromodomain: Histone Interaction Revealed by Solution NMR Driven Docking

[Image: see text] Bromodomains are epigenetic reader domains, which have come under increasing scrutiny both from academic and pharmaceutical research groups. Effective targeting of the BAZ2B bromodomain by small molecule inhibitors has been recently reported, but no structural information is yet av...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Biochemistry
Main Authors: Ferguson, Fleur M., Dias, David M., Rodrigues, João P. G. L. M., Wienk, Hans, Boelens, Rolf, Bonvin, Alexandre M. J. J., Abell, Chris, Ciulli, Alessio
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4458377/
https://ncbi.nlm.nih.gov/pubmed/25266743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi500909d
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