Structure-Based Identification of Inhibitory Fragments Targeting the p300/CBP-Associated Factor Bromodomain

[Image: see text] The P300/CBP-associated factor plays a central role in retroviral infection and cancer development, and the C-terminal bromodomain provides an opportunity for selective targeting. Here, we report several new classes of acetyl-lysine mimetic ligands ranging from mM to low micromolar...

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Pubblicato in:J Med Chem
Autori principali: Chaikuad, Apirat, Lang, Steffen, Brennan, Paul E., Temperini, Claudia, Fedorov, Oleg, Hollander, Johan, Nachane, Ruta, Abell, Chris, Müller, Susanne, Siegal, Gregg, Knapp, Stefan
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2016
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4770306/
https://ncbi.nlm.nih.gov/pubmed/26731131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b01719
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