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Targeting the cell cycle inhibitor p57(Kip2) promotes adult human β cell replication
Children with focal hyperinsulinism of infancy display a dramatic, non-neoplastic clonal expansion of β cells that have undergone mitotic recombination, resulting in paternal disomy of part of chromosome 11. This disomic region contains imprinted genes, including the gene encoding the cell cycle inh...
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| Main Authors: | , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Clinical Investigation
2014
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3904605/ https://ncbi.nlm.nih.gov/pubmed/24430183 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI69519 |
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